SHP-1 Antibody (1SH01)

Product Discontinued

SHP-1 Antibody (1SH01) Summary

• Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with recombinant human SHP1 protein and mouse myeloma NS1 cells.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTPN6
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for SHP-1 Antibody (1SH01)

• HCP
• HCPH
• HPTP1C
• PTP1C
• PTP-1C
• PTPN6
• SHP1
• SHP-1
• SHP-1L
• SH-PTP1

Background

Recognizes a protein of ~50kDa, which is identified as the SH2-containing protein-tyrosine phosphatase 1 (SHP-1). This antibody is highly specific to SHP-1 and shows no cross-reaction with other protein-tyrosine phosphatase. SHP-1 is known to play a crucial role in the regulation of hematopoiesis and it regulates the transcriptional activity stimulated by the erythropoietin (EPO)-induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis. Furthermore, the observation that SHP-1 associates with RAFTK/Pyk2/CAK activated by beta-chemokine receptor (CCR5) and SHP-1 also associates with the adaptor protein Grb2 and the Src-related kinase Syk indicates the role of SHP-1 in modulating cell migration, proliferation, and immune functions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPN6