SENP6 Antibody

Product Discontinued

SENP6 Antibody Summary

• Immunogen: Peptide with sequence AAGKSGGSAGEIT-C corresponding to N-Terminus according to NP_056386.2, NP_001093879.1.
• Localization: Cytoplasmic
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SENP6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
• Application Notes: WB: Preliminary experiments in human testis and ovary lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for SENP6 Antibody

• EC 3.4.22.-
• KIAA0797FLJ11887
• Sentrin/SUMO-specific protease SENP6
• sentrin-specific protease 6
• SSP1KIAA0389
• SUMO1/sentrin specific peptidase 6,2810017C20Rik
• SUMO1/sentrin specific protease 6
• SUMO-1-specific protease 1
• SUSP1FLJ11355

Background

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SENP6 Antibody (NB100-1308)(1)

Publication using NB100-1308

• Kim KI, Baek SH, Jeon YJ et al. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem 2000-05-12 [PMID: 10799485]

Bioinformatics

• Gene Symbol: SENP6
• Entrez:
  • 26054(Human)
• Uniprot:
  • NP_056386(Human)