Scn2b Antibody [Janelia Fluor® 585]

Product Discontinued

Scn2b Antibody [Janelia Fluor® 585] Summary

• Immunogen: Produced in rabbits immunized with purified, recombinant Human Scn2b (Accession#: O60939; Met1-Ala159)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SCN2B
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Scn2b Antibody [Janelia Fluor® 585]

• neuronal voltage-gated sodium channel beta 2 subunit
• sodium channel beta 2 subunit
• sodium channel subunit beta-2
• sodium channel, voltage-gated, type II, beta polypeptide
• sodium channel, voltage-gated, type II, beta

Background

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SCN2B