Scn2b Products

Description

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.

Bioinformatics

Entrez	6327 Human
Uniprot	AAH36793 Human NM_004588 Human
Product By Gene ID	6327
Alternate Names	neuronal voltage-gated sodium channel beta 2 subunit sodium channel beta 2 subunit sodium channel subunit beta-2 sodium channel, voltage-gated, type II, beta polypeptide sodium channel, voltage-gated, type II, beta