Nav1.5 Antibody

Images

 
Immunohistochemistry-Paraffin: Nav1.5 Antibody [NB600-804] - Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, CaSpecies Glossary
Applications IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Nav1.5 Antibody Summary

Immunogen
Peptide with sequence C-ETDDQSPEKIN corresponding to internal region according to NP_932173.1, NP_000326.2, NP_001092874.1, NP_001092875.1, NP_001153632.1, NP_001153633.1.
Specificity
This antibody is expected to recognise all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SCN5A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Preliminary experiments in lysates of human breast and heart tissues gave no specific signal but low background.
Control Peptide
Nav1.5 Peptide (NB600-804PEP)
Publications
Read Publication using NB600-804.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Nav1.5 Antibody

  • cardiac sodium channel alpha subunit
  • cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
  • CDCD2VF1
  • HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
  • HB2
  • HBBD
  • HH1CMD1E
  • ICCD
  • IVF
  • LQT3SSS1CMPD2
  • Nav1.5
  • PFHB1
  • Sodium channel protein cardiac muscle subunit alpha
  • sodium channel protein type 5 subunit alpha
  • sodium channel protein type V alpha subunit
  • Sodium channel protein type V subunit alpha
  • sodium channel, voltage-gated, type V, alpha subunit
  • Voltage-gated sodium channel subunit alpha Nav1.5

Background

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform. This antibody is expected to recognise both reported isoforms (NP_000326 and NP_932173).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Rt, Bv, Ca
Applications: IHC, IHC-P, PEP-ELISA

Publications for Nav1.5 Antibody (NB600-804)(1)

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Bioinformatics

Gene Symbol SCN5A
Entrez
Uniprot