SAMHD1 Antibody (883335) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 883335
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

SAMHD1 Antibody (883335) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human SAMHD1
  His206-Arg339
  Accession # Q9Y3Z3
• Specificity: Detects human SAMHD1 in ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SAMHD1 Antibody (883335) [Alexa Fluor® 647]

• AGS5
• CHBL2
• DCIP
• DCIPMg11
• Dendritic cell-derived IFNG-induced protein
• EC 3.1.4.-
• HDDC1
• Monocyte protein 5
• MOP5
• MOP-5
• MOP-5AGS5
• SAM domain and HD domain 1
• SAM domain and HD domain-containing protein 1
• SAMHD1
• SBBI88

Background

Human SAM (Sterile Alpha Motif) domain and HD (His/Asp motif-containing phosphohydrolase) domain-containing 1 (SAMHD1), also known as DCIP (dendritic cell IFN-g-induced protein) or MOP5 (monocyte protein 5) is a 70-80 kDa, 626 amino acid (aa) nuclear protein that acts as a dGTP-regulated deoxynucleotide triphosphohydrolase. It restricts HIV replication by binding nucleic acids. SAMHD-1 expression is induced by TNF-a in myeloid lineage cells and lung fibroblasts. Human SAMHD1 mutations are linked to Aicardi-Goutieres Syndrome, which is characterized by symptoms mimicking viral infection. Human SAMHD1 isoforms of 602, 591, and 556 aa lack aa 113-136, 502-536, and 285-354, respectively. The 591 and 556 aa forms are catalytically inactive. Within the region used as an immunogen, human SAMHD1 shares 85% aa sequence identity with mouse and rat SAMHD1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.