S100A11 Antibody (672816) [Alexa Fluor® 700]

• Applications: WB
• Clone: 672816
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

S100A11 Antibody (672816) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human S100A11
  Ala2-Thr105
  Accession # P31949
• Specificity: Detects human S100A11 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) S100A1, A2, A4, A6, A7, A8, A9, A10, A13, rhS100B, rhS100P, recombinant mouse S100A1, A4, A6, A8, A9, A10, A11, A13, or A16 is obse
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

S100A11 (also S100C and calgizzarin) is a 10-12 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins.  It is produced by smooth muscle and keratinocytes. Intracellularly, it suppresses growth; extracellularly, it exists as both a monomer, homodimer, and heterodimer with S100B, binds to RAGE, induces EGF, and promotes cell growth.  Human S100A11 is 105 amino acids (aa) in length.  It contains two EF-hand motifs (aa 13-49 and 55-90) and one high-affinity Ca-binding site (aa 68-79), and binds annexin I with its C-terminal half.  There may be one alternative splice form that apparently contains a series of mutations over aa 61-79 and shows 90% overall aa identity to the standard form.  Full-length human S100A11 shares 78% and 82% aa identity with mouse and porcine S100A11, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.