S100A11 Antibody (493804) [Alexa Fluor® 488]

• Reactivity: Mu
• Applications: WB
• Clone: 493804
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 488

S100A11 Antibody (493804) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant mouse S100A11
  Met1-Ile98
  Accession # P50543
• Specificity: Detects mouse S100A11 in direct ELISAs and Western blots. In direct ELISAs, ;no cross-reactivity with recombinant mouse S100A1, 4, 6, 8, 9, 10, 13, or 16 is observed, and approximately 75% cross‑reactivity with recombinant human (rh) S100A11 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for S100A11 Antibody (493804) [Alexa Fluor® 488]

• Calgizzarin
• Metastatic lymph node gene 70 protein
• MLN 70
• MLN70
• protein S100-A11
• Protein S100-C
• S100 calcium binding protein A11
• S100 calcium-binding protein A11 (calgizzarin)
• S100 calcium-binding protein A11
• S100A11
• S100C
• S100CS100 calcium binding protein A11 (calgizzarin)

Background

S100A11, also called calgizzarin or S100C, is an antiproliferative 10 kDa protein that is a member of the S100 family of EF-hand calcium binding proteins. It is found in the cytosol of proliferating fibroblasts and keratinocytes, but in the nucleus in differentiating cells. TGF-beta treatment or calcium-induced S100A11 serine phosphorylation induces nuclear translocation of S100A11 and subsequent growth inhibition in normal cells. The 98 amino acid (aa) mouse S100A11 shares 82% and 94% aa identity with human and rat S100A11, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.