WB: Detects an approx. 565 kDa protein representing the ryanodine receptor. In non-mammalian vertebrates, a doublet is seen at 565 kDa representing the alpha and beta isoforms of the receptor. IHC: Staining of RyR in rat cardiac tissue results in intense staining of the myofiber, which is consistent with sarcoplasmic reticulum localization.
Read Publication using NB120-2827 in the following applications:
Porcine reactivity reported in scientific literature (PMID: 12456488). Bovine (PMID: 15896674).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Ascites diluted with PBS
0.05% Sodium Azide
Alternate Names for Ryanodine Receptor 1 Antibody (C3-33)
central core disease of muscle
ryanodine receptor 1 (skeletal)
ryanodine receptor 1
ryanodine receptor type1
sarcoplasmic reticulum calcium release channel
Skeletal muscle calcium release channel
skeletal muscle ryanodine receptor
Skeletal muscle-type ryanodine receptor
type 1-like ryanodine receptor
The Ryanodine Receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR 1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR 2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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