Ryanodine Receptor 1 Antibody (C3-33)

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Immunocytochemistry/ Immunofluorescence: Ryanodine Receptor 1 Antibody (C3-33) [NB120-2827] - Immunolocalization of RyR1 in rat brain hippocampus.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Am, Bv, Ca, Ch, Fi, GP, RbSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Clone
C3-33
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Ryanodine Receptor 1 Antibody (C3-33) Summary

Immunogen
Canine cardiac ryanodine receptor.
Localization
Membrane; Multi-pass membrane protein
Specificity
Detects ryanodine receptor 2 (RyR 2) and weakly detects RyR 1.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
RYR1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/Immunofluorescence 1:50
  • Immunohistochemistry 1 ug/ml
  • Immunohistochemistry-Frozen 1 ug/ml
  • Immunohistochemistry-Paraffin 1 ug/ml
  • Immunoprecipitation 1:10 - 1:500
Application Notes
WB: Detects an approx. 565 kDa protein representing the ryanodine receptor. In non-mammalian vertebrates, a doublet is seen at 565 kDa representing the alpha and beta isoforms of the receptor. IHC: Staining of RyR in rat cardiac tissue results in intense staining of the myofiber, which is consistent with sarcoplasmic reticulum localization.
Publications
Read Publication using
NB120-2827 in the following applications:

  • WB
    1 publication

Reactivity Notes

Porcine reactivity reported in scientific literature (PMID: 12456488). Bovine (PMID: 15896674).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Ascites diluted with PBS
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for Ryanodine Receptor 1 Antibody (C3-33)

  • CCO
  • central core disease of muscle
  • MHS
  • MHS1
  • ryanodine receptor 1 (skeletal)
  • ryanodine receptor 1
  • ryanodine receptor type1
  • RYDR
  • RYR
  • RyR1
  • RYR-1
  • sarcoplasmic reticulum calcium release channel
  • Skeletal muscle calcium release channel
  • skeletal muscle ryanodine receptor
  • Skeletal muscle-type ryanodine receptor
  • SKRR
  • type 1-like ryanodine receptor

Background

The Ryanodine Receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR 1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR 2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Ryanodine Receptor 1 Antibody (NB120-2827)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.


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WB
(1)
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Rat
(1)
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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol RYR1
Entrez
Uniprot