Rit2 Antibody - BSA Free

Immunohistochemistry-Paraffin: Rit2 Antibody [NBP2-68932] - Staining of human liver shows no positivity in hepatocytes as expected.

Immunohistochemistry: Rit2 Antibody [NBP2-68932] - Immunohistochemical staining of human cerebellum shows moderate membraneous positivity in molecular layer.

Immunohistochemistry-Paraffin: Rit2 Antibody [NBP2-68932] - Staining of human adrenal gland shows weak to moderate cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: Rit2 Antibody [NBP2-68932] - Staining of human tonsil shows no positivity in non-germinal center cells as expected.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Rit2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: MEVENEASCSPGSASGGSREYKVVM
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RIT2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: Recommended conditions for IHC,Retrieval method: HIER pH6
• Control Peptide:

  Rit2 Recombinant Protein Antigen (NBP2-68932PEP)

Reactivity Notes

Mouse 88%, Rat 84%

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Protein A purified

Alternate Names for Rit2 Antibody - BSA Free

• GTP-binding protein Rit2
• GTP-binding protein Roc2
• Ras-like protein expressed in neurons
• Ras-like without CAAX 2
• Ras-like without CAAX protein 2
• RIBA
• Ric (Drosophila)-like, expressed in neurons
• Ric-like, expressed in neurons
• RIN
• Rit2
• ROC2

Background

RIT2 is a gene that codes for a protein which binds and exchanges GTP and GDP, and has two isoforms with lengths of 217 and 153 amino acids, with weights of approximately 25 and 17 kDa, respectively. Current studies are being done on diseases and disorders relating to this gene including neuronitis, ehrlichiosis, cryoglobulinemia, hepatitis, Parkinson's disease, and schizophrenia. RIT2 has been shown to have interactions with CALM1, CALM2, CALM3, RLF, and HRAS in pathways such as the Trk receptor signaling, signaling to NGF, and signaling to ERKs pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RIT2