RHBDF2 Antibody (996308) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 996308
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

RHBDF2 Antibody (996308) [Alexa Fluor® 750] Summary

• Immunogen: Synthetic peptide containing human iRHOM2/RHBDF2
  Accession # Q6PJF5
• Specificity: Detects huma iRHOM2/RHBDF2 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RHBDF2 Antibody (996308) [Alexa Fluor® 750]

• FLJ22341
• iRHOM2
• RHBDF2
• RHBDL5
• RHBDL5rhomboid family member 2
• RHBDL6
• rhomboid 5 homolog 2 (Drosophila)
• Rhomboid 5 homolog 2
• rhomboid veinlet-like 5
• Rhomboid veinlet-like protein 5
• Rhomboid veinlet-like protein 6
• rhomboid, veinlet-like 6 (Drosophila)
• rhomboid, veinlet-like 6
• rhomboid-like protein 6
• TOCG

Background

Human Inactive rhomboid protein 2 (RHBDF2 or IRHOM2) is a highly conserved seven-transmembrane Rhomboid protease-like protein which is inactive, it has no protease activity, but has been implicated in the secretion of several ligands of the epidermal growth factor receptor (EGFR), probably by regulating trafficking and stability of key protein membrane like ADAM17 and STING. The RHBDF2 protein plays an important role in the secretion of tumor necrosis factor alpha and has been implicated in familial esophageal cancer. Gain-of-function (GOF) mutations in the RHBDF2 gene constitutively activate EGFR signaling to cause tylosis with esophageal cancer syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q6PJF5(Mouse)