RHBDF2 Antibody (996308) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clone: 996308
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

RHBDF2 Antibody (996308) [Alexa Fluor® 700] Summary

• Immunogen: Synthetic peptide containing human iRHOM2/RHBDF2
  Accession # Q6PJF2
• Specificity: Detects huma iRHOM2/RHBDF2 in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RHBDF2 Antibody (996308) [Alexa Fluor® 700]

• FLJ22341
• iRHOM2
• RHBDF2
• RHBDL5
• RHBDL5rhomboid family member 2
• RHBDL6
• rhomboid 5 homolog 2 (Drosophila)
• Rhomboid 5 homolog 2
• rhomboid veinlet-like 5
• Rhomboid veinlet-like protein 5
• Rhomboid veinlet-like protein 6
• rhomboid, veinlet-like 6 (Drosophila)
• rhomboid, veinlet-like 6
• rhomboid-like protein 6
• TOCG

Background

Human Inactive rhomboid protein 2 (RHBDF2 or IRHOM2) is a highly conserved seven-transmembrane Rhomboid protease-like protein which is inactive, it has no protease activity, but has been implicated in the secretion of several ligands of the epidermal growth factor receptor (EGFR), probably by regulating trafficking and stability of key protein membrane like ADAM17 and STING. The RHBDF2 protein plays an important role in the secretion of tumor necrosis factor alpha and has been implicated in familial esophageal cancer. Gain-of-function (GOF) mutations in the RHBDF2 gene constitutively activate EGFR signaling to cause tylosis with esophageal cancer syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.