Mouse reactivity reported in scientific literature (PMID: 17576169).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
0.1 ml crude whole Rabbit sera with 50% Glycerol
0.025% Sodium Azide
Alternate Names for RGS18 Antibody
regulator of G-protein signaling 18
regulator of G-protein signalling 13
RGS13regulator of G-protein signalling 18
Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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