Ret Antibody

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Western Blot: Ret Antibody [NBP1-19866] - extracts from K562 cells.

Product Details

Summary
Product Discontinued
View other related Ret Primary Antibodies

Order Details


    • Catalog Number
      NBP1-19866
    • Availability
      Product Discontinued

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Ret Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 1011-1060 of Human Ret.
Clonality
Polyclonal
Host
Rabbit
Gene
RET
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Theoretical MW
175 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Ret Antibody

  • CDHF12MTC1
  • CDHR16
  • EC 2.7.10
  • Hirschsprung disease 1
  • Hirschsprung disease)
  • MEN2A
  • MEN2B
  • multiple endocrine neoplasia and medullary thyroid carcinoma 1
  • ret proto-oncogene
  • RET transforming sequence
  • Ret

Background

The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. By alternative splicing, two isoforms of the Ret proto-oncogene product are generated. The isoforms differ from each other by having either 9 or 51 carboxy terminal amino acids. The Ret gene products include two glycosylated proteins in tunicamycin treated cells, a non-glycosylated protein consistent with the predicted Ret molecular weight based on sequence analysis. Tumorspecific rearrangements of the Ret proto-oncogene have been identified in papillary thyroid carcinomas leading to the formation of different transforming fusion proteins sharing the tyrosine kinase domain of Ret. In contrast to the Ret proto-oncogene, the rearranged forms are constitutively phosphorylated on tyrosine and are translocated from the membrane to the cytoplasm.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Additional Ret Products

Bioinformatics Tool for Ret Antibody (NBP1-19866)

Discover related pathways, diseases and genes to Ret Antibody (NBP1-19866). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Ret Antibody (NBP1-19866)

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Pathways for Ret Antibody (NBP1-19866)

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PTMs for Ret Antibody (NBP1-19866)

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Research Areas for Ret Antibody (NBP1-19866)

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Blogs on Ret.

Beta III tubulin
The Beta III tubulin protein is abundantly present in both the central and peripheral nervous systems (CNS and PNS), where it is predominantly expressed during fetal and postnatal development. In cerebellar and sympathoadrenal neurogenesis, Beta III d...  Read full blog post.

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Bioinformatics

Gene Symbol RET
Entrez
Uniprot