Recombinant Mouse IL-13 R alpha 1 Fc Chimera Protein, CF

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Mouse IL-13 R alpha 1 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit IL-13-dependent proliferation of TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.2-0.8 µg/mL in the presence of 4 ng/mL rmIL-13.
Source
Mouse myeloma cell line, NS0-derived mouse IL-13 R alpha 1 protein
Mouse IL-13 R alpha 1
(Ala25 - Thr340)
Accession # O09030
DIEGR Human IgG1
(Pro100 - Lys330)
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Ala25
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
Il13ra1
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
63 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
100-120 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 200 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-13 R alpha 1 Fc Chimera Protein, CF

  • bB128O4.2.1 (interleukin 13 receptor, alpha 1)
  • Cancer/testis antigen 19
  • CD213a1 antigen
  • CD213a1
  • CT19
  • IL-13 R alpha 1
  • IL13 receptor alpha-1 chain
  • IL-13 receptor subunit alpha-1
  • IL13R alpha 1
  • IL-13R subunit alpha-1
  • IL13R
  • IL13RA
  • IL-13Ra
  • IL13RA1
  • IL-13Ra1
  • IL-13R-alpha-1
  • interleukin 13 receptor, alpha 1
  • interleukin-13 receptor subunit alpha-1
  • NR4

Background

Mouse IL-13 receptor alpha one (IL‑13 R alpha 1), previously called NR4, IL-13 R alpha, and IL13R alpha ', is a member of the hemopoietin receptor family that was cloned on the basis of its conserved WSXWS motif. Mouse IL‑13 R alpha 1 encodes a 424 amino acid (aa) residue precursor type I membrane protein with a 26 aa residue signal peptide, a 314 aa residue extracellular domain (containing an immunoglobulin-like domain and a typical hemopoietin receptor domain), a 24 aa residue transmembrane region and a 60 aa residue cytoplasmic tail. Human IL‑13 R alpha 1, with 76% amino acid sequence identity to mouse IL‑13 R alpha 1, has also been cloned. In addition, a second human IL‑13 binding protein, designated IL‑13 R alpha 2 and previously known as IL‑13 R beta, IL‑13 R and IL‑13 R alpha, has been cloned from the Caki‑1 human renal carcinoma cell line. Murine IL‑13 R alpha 2 has been cloned from a mouse thymus cDNA library. The amino terminal 27 amino acid residues of the human and mouse IL‑13 R alpha 2 is nearly identical to that of a soluble mouse IL ‑3 binding proteinpurified from mouse serum and urine.

Both human and mouse IL‑13 R alpha 2 and mouse IL‑13 binding protein bind IL‑13 with high‑affinity. In cells transfected with mouse IL‑13 R alpha 1 only, low‑affinity binding with mouse IL13 is observed. However, in cells expressing both the mouse IL‑13 R alpha 1 and mouse IL4 receptor, a high affinity IL‑13 receptor complex capable of transducing an IL‑13 or IL‑4‑dependent proliferative signal, is generated.These results suggest that mouse IL‑13 R alpha 1, in addition to its role as a IL‑13 binding subunit in the IL‑13 receptor complex, can serve as an alternative to the common gamma chain for IL‑4 signaling.

  1. Hilton, D.J. et al. (1996) Proc. Natl. Acad. Sci. USA 93:497.
  2. Aman, M.J. et al. (1996) J. Biol. Chem. 271:29265.
  3. Caput, D. et al. (1996) J. Biol. Chem. 271:16921.
  4. Zhang, J.G. et al. (1997) J. Biol. Chem. 272:9474.
  5. Obiri, N.I. et al. (1997) J. Immunol. 158:756.
  6. Donaldson, D.D. et al. (1998) J. Immunol. 161:2317.

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Bioinformatics

Gene Symbol Il13ra1
Entrez
Uniprot