Recombinant Mouse BMPR-IA/ALK-3 Fc Chimera Protein

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity

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Recombinant Mouse BMPR-IA/ALK-3 Fc Chimera Protein Summary

Additional Information
A New rm BMPR-IA is Available! It has ~1.5 fold better, lower endotoxin specification, and a Fc tag!
Details of Functionality
Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50 for this effect is 0.05-0.2 µg/mL in the presence of 30 ng/mL of recombinant human BMP-4.
Source
Mouse myeloma cell line, NS0-derived mouse BMPR-IA/ALK-3 protein
Mouse BMPR-IA
(Gln24 - Arg152)
Accession # Q60607
IEGRMD Human IgG1
(Pro100 - Lys330)
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
No results obtained: Gln24 predicted
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
Bmpr1a
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
41.5 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
55 kDa, reducing conditions
Publications
Read Publications using
437-MR in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse BMPR-IA/ALK-3 Fc Chimera Protein

  • ACVRLK310q23del
  • ALK-3
  • ALK3EC 2.7.11.30
  • BMP type-1A receptor
  • BMPR1A
  • BMPR-1A
  • BMPRIA
  • BMPR-IA
  • bone morphogenetic protein receptor type-1A
  • bone morphogenetic protein receptor, type IA
  • CD292 antigen
  • CD292
  • EC 2.7.11
  • Serine/threonine-protein kinase receptor R5
  • SKR5
  • type II-like kinase 3

Background

Bone Morphogenetic Protein Receptor IA (BMPR-IA), also known as ALK-3, BRK-1, and CD292, is a glycosylated 60 ‑ 65 kDa type I receptor in the TGF‑ beta serine/threonine kinase receptor family (1 ‑ 3). Binding of TGF‑ beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins (1, 2). Mature mouse BMPR-IA consisits of a 129 amino acid (aa) extracellular domain (ECD), a 24 aa transmembrane segment, and a 356 aa cytoplasmic region that contains the tyrosine kinase domain (4, 5). Within the ECD, mouse BMPR-IA shares 98% aa sequence identity with human and rat BMPR-IA. BMPR-IA is involved in the development and function of a wide range of tissues. During early embryogenesis it is required for migration of the anterior visceral endoderm (AVE) and proper development of the anterior-posterior axis (6). Tissue-specific conditional knockout experiments have demonstrated the importance of BMPR-IA in the development and morphogenesis of the heart, lung, palate, teeth, and mandible (7 - 9). In the adult, BMPR-IA plays a role in glucose-stimulated insulin secretion by pancreatic beta cells, osteoclast activity and bone remodeling, reactive astrocyte-mediated scar formation following spinal cord injury, and ovulation and fertility (10 - 13).
  1. Wu, M.Y. and C.S. Hill (2009) Dev. Cell 16:329.
  2. Nickel, J. et al. (2009) Cytokine Growth Factor Rev. 20:367.
  3. de Caestecker, M. (2004) Cytokine Growth Factor Rev. 15:1.
  4. Dewulf, N. et al. (1995) Endocrinology 136:2652.
  5. Koenig, B.B. et al. (1994) Mol. Cell. Biol. 14:5961.
  6. Miura, S. et al. (2010) Dev. Biol. 341:246.
  7. Gaussin, V. et al. (2002) Proc. Natl. Acad. Sci. 99:2878.
  8. Sun, J. et al. (2008) Am. J. Pathol. 172:571.
  9. Li, L. et al. (2011) Dev. Biol. 349:451.
  10. Goulley, J. et al. (2007) Cell Metab. 5:207.
  11. Kamiya, N. et al. (2008) J. Bone Miner. Res. 23:2007.
  12. Sahni, V. et al. (2010) J. Neurosci. 30:1839.
  13. Edson, M.A. et al. (2010) Mol. Endocrinol. 24:1251.

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437-MR
Species: Mu
Applications: Bioactivity

Publications for BMPR-IA/ALK-3 (437-MR)(4)

We have publications tested in 2 confirmed species: Mouse, N/A.

We have publications tested in 3 applications: Bioassay, ELISA (Standard), In Vivo.


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Bioassay
(2)
ELISA (Standard)
(1)
In Vivo
(1)
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Mouse
(3)
N/A
(1)
All Species

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Bioinformatics

Gene Symbol Bmpr1a
Uniprot