Recombinant Human Wnt-11 Protein, CF


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Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human Wnt-11 Protein, CF Summary

Details of Functionality
Measured in a cell proliferation/survival assay using IEC‑18 rat small intestinal epithelial cells. The ED50 for this effect is 0.6-2.4 μg/mL.
Chinese Hamster Ovary cell line, CHO-derived human Wnt-11 protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
36.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
38-40 kDa, reducing conditions
Read Publications using
6179-WN/CF in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Wnt-11 Protein, CF

  • HWNT11
  • MGC141946
  • MGC141948
  • protein Wnt-11
  • wingless-type MMTV integration site family, member 11
  • Wnt11
  • Wnt-11


Wnt‑11 belongs to the Wnt family of secreted, highly conserved, cysteine-rich cell signaling glycoproteins that play important roles in vertebrate developmental pattern formation, cell fate decision, axon guidance, and tumor formation (1-3). Mature human Wnt‑11 shares 98% amino acid (aa) sequence identity with mouse, rat and bovine Wnt‑11, and 99%, 96% and 88% aa identity with canine, equine and chick Wnt‑11, respectively. Mouse Wnt‑11 is expressed in early development during gastrulation and in the perichondrium, lung mesenchyme and ureteric buds, but not in neuroepithelium (1). It is required for cardiogenesis, organization of early muscle fibers, and branching morphogenesis of ureters (3-7). It is also expressed in several human cancers (2). In vitro, Wnt‑11 has been shown to induce cardiomyocyte differentiation from unfractionated mouse bone marrow mononuclear cells, and to promote hematopoietic differentiation from human embryoid body stem cells by engaging Frizzled-7 in the presence of E-cadherin (6, 8). In general, there are three signaling pathways associated with Wnt‑receptor interaction. The canonical pathway results in beta -Catenin accumulation and TCF/LEF‑1‑mediated gene transcription. Non‑canonical pathways include the Wnt/Ca2+ pathway and the planar cell polarity (PCP) pathway. Wnt‑11 often, but not exclusively, signals by a non‑canonical pathway and may repress canonical signaling by other Wnts (2, 9). However, when complexed with Wnt‑5a, Wnt‑11 can also enhance canonical signaling (10).

  1. Lako, M. et al. (1998) Gene 219:101.
  2. Katoh, M. and M. Katoh (2009) Int. J. Mol. Med. 24:247.
  3. Flaherty, M.P. and B. Dawn (2008) Trends Cardiovasc. Med. 18:260.
  4. Gros, J. et al. (2009) Nature 457:589.
  5. Pandur, P. et al. (2002) Nature 418:636.
  6. Flaherty, M.P. et al. (2008) Circulation 117:2241.
  7. Majumdar, A. et al. (2003) Development 130:3175.
  8. Vijayaragavan, K. et al. (2009) Cell Stem Cell 4:248.
  9. Maye, P. et al. (2004) J. Biol. Chem. 279:24659.
  10. Cha, S-W. et al. (2009) Curr. Biol. 19:1573.

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Publications for Wnt-11 (6179-WN/CF)(18)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Transgenic Mouse, Zebrafish.

We have publications tested in 5 applications: Bioassay, Differentiation, ICC, In Vivo, Western Blot.

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Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using 6179-WN/CF Applications Species
N Salerno, F Marino, M Scalise, L Salerno, C Molinaro, A Filardo, A Chiefalo, G Panuccio, A De Angelis, K Urbanek, D Torella, E Cianflone Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice Mechanisms of Ageing and Development, 2022-09-20;208(0):111740. 2022-09-20 [PMID: 36150603] (Differentiation, Differentiation, Mouse) Differentiation, Differentiation Mouse
AK Heilig, R Nakamura, A Shimada, Y Hashimoto, Y Nakamura, J Wittbrodt, H Takeda, T Kawanishi Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis Elife, 2022-05-06;11(0):. 2022-05-06 [PMID: 35522214] (In Vivo, Zebrafish) In Vivo Zebrafish
B ?wierczek-, D Dudka, D Bauer, T Czajkowski, K Ilach, W Streminska, A Kominek, K Piwocka, MA Ciemerych, K Archacka Comparison of Differentiation Pattern and WNT/SHH Signaling in Pluripotent Stem Cells Cultured under Different Conditions Cells, 2021-10-14;10(10):. 2021-10-14 [PMID: 34685722] (Bioassay, Mouse) Bioassay Mouse
ED Arisan, O Rencuzogul, C Cieza-Borr, F Miralles A, M Dwek, S Lange, P Uysal-Onga MiR-21 Is Required for the Epithelial-Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells International Journal of Molecular Sciences, 2021-02-04;22(4):. 2021-02-04 [PMID: 33557112] (ICC, Western Blot, Human) ICC, Western Blot Human
A Böttcher, M Büttner, S Tritschler, M Sterr, A Aliluev, L Oppenlände, I Burtscher, S Sass, M Irmler, J Beckers, C Ziegenhain, W Enard, AC Schamberge, FM Verhamme, O Eickelberg, FJ Theis, H Lickert Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates Nature Cell Biology, 2021-01-04;23(1):23-31. 2021-01-04 [PMID: 33398177] (Bioassay, Transgenic Mouse) Bioassay Transgenic Mouse
I Rodriguez-, O Maiques, L Kohlhammer, G Cantelli, A Perdrix-Ro, J Monger, B Fanshawe, VL Bridgeman, SN Karagianni, RM Penin, J Marcolval, RM Marti, X Matias-Gui, GO Fruhwirth, JL Orgaz, I Malanchi, V Sanz-Moren WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion Nat Commun, 2020-10-20;11(1):5315. 2020-10-20 [PMID: 33082334] (Bioassay, Human) Bioassay Human
W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-12-30;0(0):. 2019-12-30 [PMID: 31648393] (Bioassay, Mouse) Bioassay Mouse
P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon Precardiac organoids form two heart fields via Bmp/Wnt signaling Nat Commun, 2018-08-07;9(1):3140. 2018-08-07 [PMID: 30087351] (Mouse) Mouse
BD Boyan, R Olivares-N, MB Berger, SL Hyzy, Z Schwartz Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces Sci Rep, 2018-06-05;8(1):8588. 2018-06-05 [PMID: 29872092] (Bioassay, Human) Bioassay Human
DE Reichman, L Park, L Man, D Redmond, K Chao, RP Harvey, MM Taketo, Z Rosenwaks, D James Wnt inhibition promotes vascular specification of embryonic cardiac progenitors Development, 2018-01-08;145(1):. 2018-01-08 [PMID: 29217753] (Differentiation, Differentiation, Human) Differentiation, Differentiation Human
Show All 18 Publications.

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Gene Symbol WNT11