Recombinant Human IFN-alpha B2 (alpha 8) Protein

• Reactivity: Hu

Recombinant Human IFN-alpha B2 (alpha 8) Protein Summary

• Protein/Peptide Type: Recombinant Proteins
• Gene: IFNA8

Applications/Dilutions

Publications

Read Publications using 11115-1 in the following applications: Bioassay 2 publications

Packaging, Storage & Formulations

• Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IFN-alpha B2 (alpha 8) Protein

• IFNA8
• IFN-alpha 8
• IFNalpha B2
• IFN-alpha B2
• IFN-alpha-8
• IFN-alphaB
• interferon alpha type 201
• interferon alpha-8
• Interferon alpha-B
• interferon alpha-B'
• Interferon alpha-B2
• interferon, alpha 8
• LeIF B

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Publications for IFN-alpha B2/IFN-alpha 8 (11115-1)(2)

Publications using 11115-1

• Liu Q, Tomei S, Ascierto M, De Giorgi V, Bedognetti D, Dai C, Uccellini L, Spivey T, Pos Z, Thomas J, Reinboth J, Murtas D, Zhang Q, Chouchane L, Weiss G, Slingluff C, Lee P, Rosenberg S, Alter H, Yao K, Wang E, Marincola F Melanoma NOS1 expression promotes dysfunctional IFN signaling. J Clin Invest, 2014-04-01;124(5):2147-59. 2014-04-01 [PMID: 24691438] (Bioassay, Human)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)

Bioinformatics

• Gene Symbol: IFNA8