Western Blot: RBBP6 Antibody [NBP1-49535] - Analysis of RbBP6 in HeLa nuclear extracts.
Immunohistochemistry-Paraffin: RBBP6 Antibody [NBP1-49535] - IHC analysis of formalin-fixed paraffin-embedded tissue section from intestine of normal mouse with 1:400 dilution of RBBP6 antibody. The intestinal ...read more
Immunohistochemistry-Paraffin: RBBP6 Antibody [NBP1-49535] - IHC analysis of formalin-fixed paraffin-embedded tissue section from skin of normal mouse with 1:400 dilution of RBBP6 antibody. The keratinocytes and other ...read more
Independent Antibodies: Immunoprecipitation: RBBP6 Antibody [NBP1-49535] - Immunoprecipitation of RbBP6 from HeLa cells using A. NBP1-49542 and B. NBP1-49535.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 30% Glycerol
0.05% Sodium Azide
Immunogen affinity purified
Alternate Names for RBBP6 Antibody
E3 ubiquitin-protein ligase RBBP6
p53-associated cellular protein of testis
Proliferation potential-related protein
RB-binding Q-protein 1
retinoblastoma binding protein 6
Retinoblastoma-binding protein 6DKFZp686P0638
Retinoblastoma-binding Q protein 1
RBBP6 (retinoblastoma binding protein 6; P2PR, PACT, RBQ1) is a multidomain protein with an expected molecular size of about 250kD and it colocalizes with mitotic chromosomes as well as with NEK6 in centrosomes. RBBP6 is highly expressed in normal placenta and testis, and is overexpressed in certain cancers (esophageal and lung cancer). RBBP6 is a multifunctional protein which is found presumably in all eukaryotes and is implicated in versatile cellular activities such as mRNA metabolism, cell cycle regulation, carcinogenesis, and development. It forms part of the pre-mRNA 3-end processing complex in humans and the cleavage/polyadenylation factor complex in yeast. RBBP6 interacts with p53/TP53, RB1, NEK6, MDM2, YBX1 etc., and gets phosphorylated upon DNA damage via ATM/ATR or through NEK6. RBBP6 is an E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, thereby facilitating its proteasomal degradation. RBBP6 also acts as a scaffold protein to enhance the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, thereby acting as a negative regulator of p53/TP53.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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