Western Blot: RBBP4/RbAp48 Antibody [NB100-60399] - Whole cell lysate from HeLa (5, 15, and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug), and mouse NIH3T3 (M; 50 ug) cells. Antibodies: NB100-60399 used ...read more
Immunohistochemistry-Paraffin: RBBP4/RbAp48 Antibody [NB100-60399] - Sample: FFPE section of human Ewing sarcoma. Antibody: Affinity purified rabbit anti- RBBP4/RbAp48 used at a dilution of 1:200 (1ug/ml). Detection: DAB
The immunogen recognized by this antibody maps to a region between residue 1 and 50 of human retinoblastoma binding protein 4 (retinoblastoma-binding protein p48) using the numbering given in entry CAA52321.1 (GeneID 5928).
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
48 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Retinoblastoma-binding protein 4CAF-I 48 kDa subunit
Retinoblastoma-binding protein p48
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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