Western Blot: RB1CC1 Antibody [NB100-77279] - Detection of Mouse FIP200/RB1CC1 by Western Blot. Samples: Whole cell lysate from TCMK-1 (15 and 50 ug) cells. Antibodies: Affinity purified rabbit anti-FIP200/RB1CC1 ...read more
Independent Antibodies: Western Blot: RB1CC1 Antibody [NB100-77279] - Detection of Human FIP200/RB1CC1 on HeLa whole cell lysate using NB100-77279. FIP200/RB1CC1 was also immunoprecipitated by rabbit ...read more
The immunogen recognized by this antibody maps to a region between residue 1544 and 1594 of human 200 kDa FAK family kinase-interacting protein (RB1-inducible coiled-coil 1) using the numbering given in entry NP_055596.2 (GeneID 9821).
Immunogen affinity purified
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183 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
KIAA0203200 kDa FAK family kinase-interacting protein
RB1-inducible coiled-coil 1
RB1-inducible coiled-coil protein 1
FIP200 (FAK-family interacting protein of 200 kDa) appears to play several key roles related to cell growth, proliferation, development, and tumorigenesis. FIP200 was originally identified in a yeast two-hybrid screen for Pyk2 kinase interacting proteins. It was later identified as a protein that interacts with FAK (focal adhesion kinase), a signal transducing protein that mediates signals from the extracellular matrix to the cytoskeleton to influence cell motility, and cell cycle progression. FIP200 is also known as RB1CC1 (RB1-inducible coiled-coil 1) and has been found to function as a regulator of the retinoblastoma 1 (RB1) tumor suppressor. FIP200 associates with the tumor suppressor TSC1 which partners with TSC2 to antagonize the mTOR signaling pathway. FIP200 association with TSC2 promotes mTOR activity by interfering with the antagonistic effects of the TSC1-TSC2 complex.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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