RAB39 Recombinant Protein Antigen

• Reactivity: Hu
• Applications: AC

RAB39 Recombinant Protein Antigen Summary

• Description: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human RAB39A.
  
  

  Source: E. coli

  Amino Acid Sequence: SQRQVTREEAEKLSADCGMKYIETSA

  Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)

  This product is intended to be used as a blocking antigen for antibody competition assays. Any other use of this antigen is done at the risk of the user. The use of this product for commercial production is strictly prohibited. Please contact technical support if you have any questions.

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein Antigen
• Gene: RAB39A
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • Antibody Competition 10 - 100 molar excess
• Application Notes: This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP2-13193.

  It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.

  For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com

• Theoretical MW: 21 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS and 1M Urea, pH 7.4.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Alternate Names for RAB39 Recombinant Protein Antigen

• rab-39
• RAB39, member RAS oncogene family
• RAB39A
• rab-related GTP-binding protein
• ras-related protein Rab-39A

Background

Belonging to the small GTPase superfamily/ Rab family, RAB39 plays an important role in cell formation and vesicular trafficking. More specifically, RAB39 proteins are involved in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. It also plays a role in the fusion of phagosomes with lysosomes. Additionally, the main molecular functions include GTP and nucleotide binding. RAB39 interacts with ATG5, CLN3, GABARAPL1, SH3GLB2 and STK11 and diseases include ataxia telangiectasia and malaria.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: RAB39A