PTPN21 Antibody

Immunohistochemistry-Paraffin: PTPN21 Antibody [NBP3-12337] - Mouse Spleen. 1:50 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

• Reactivity: Hu, Mu, Rt, Ch, Pm
• Applications: WB, ELISA, IHC, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

PTPN21 Antibody Summary

• Description: Novus Biologicals Rabbit PTPN21 Antibody (NBP3-12337) is a polyclonal antibody validated for use in IHC, WB, ELISA and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide taken within amino acid region 400-500 on mouse PTPND1 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPN21
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:1000
  • Immunohistochemistry 1:50-1:150
  • Immunohistochemistry-Paraffin 1:50-1:150
  • Immunoprecipitation 1:200
  • Western Blot 1:250

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for PTPN21 Antibody

• dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
• EC 3.1.3
• EC 3.1.3.48
• protein tyrosine phosphatase, non-receptor type 21
• Protein-tyrosine phosphatase D1
• PTPD1
• PTPD1protein tyrosine phosphatase D1
• PTPN21
• PTPRL10
• tyrosine-protein phosphatase non-receptor type 21

Background

PTPN21 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPN21