PTPN21 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
|Product By Gene ID
- EC 18.104.22.168
- EC 3.1.3
- Protein-tyrosine phosphatase D1
- tyrosine-protein phosphatase non-receptor type 21
- PTPD1protein tyrosine phosphatase D1
- dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
- protein tyrosine phosphatase, non-receptor type 21
Bioinformatics Tool for PTPN21
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