PTP alpha/PTPRA Antibody

Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NLS6794] - Analysis of anti-PTPRA antibody with human breast, epithelium at dilution 4 ug/ml.

Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NLS6794] - Analysis of anti-PTPRA antibody with human, skeletal muscle.

Product Discontinued

PTP alpha/PTPRA Antibody Summary

• Immunogen: Synthetic 18 amino acid peptide from cytoplasmic domain of human PTPRA.
• Specificity: Human PTPRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPRE (67%).
• Predicted Species: Opossum (100%), Fish (100%), Turkey (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPRA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (100%), Seabass (100%), Stickleback (100%), Medaka (100%), Pufferfish (100%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PTP alpha/PTPRA Antibody

• EC 3.1.3.48
• HEPTP
• HLPR
• LRP
• LRPHPTPalpha
• protein tyrosine phosphatase, receptor type, A
• Protein-tyrosine phosphatase alpha
• PTP alpha
• PTPAreceptor type, alpha polypeptide
• PTPase-alpha
• PTPLCA-related phosphatase
• PTPRA
• PTPRL2
• receptor-type tyrosine-protein phosphatase alpha
• RPTPA
• R-PTP-alpha
• tyrosine phosphatase alpha

Background

PTP alpha, a R4 receptor protein tyrosine phosphatase, is implicated in neuron formation, retinal development, cell adhesion, potassium channel regulation, nerve repair, insulin signaling, and cell cycle regulation. PTP alpha activates the Src protein tyrosine kinase during mitosis, resulting in the transition from G2 to mitosis in the cell cycle. PTP alpha is associated with carcinomas of breast, colon, oral squamous cell and prostate. A cytosolic form of PTP alpha, p66 PTP alpha, has recently been isolated. p66 PTP alpha is produced by calpain-mediated proteolytic cleavage and its expression has been detected in nearly all cell types where PTP alpha is expressed. PTP alpha expression has been documented in human neoplastic breast, colon, prostate, and oral tissues, as well as in normal adipose, liver, skeletal muscle, and endothelial cells. ESTs have been isolated from a diverse set of normal and cancerous tissue libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRA
• Entrez:
  • 5786(Human)
• Uniprot:
  • P18433(Human)