PTP alpha/PTPRA Antibody (5G3)

Western Blot: PTP alpha Antibody (5G3) [NBP2-29759] - HeLa cell lysate probed with anti-PTPA (1:5,000 dilution).

Product Discontinued

PTP alpha/PTPRA Antibody (5G3) Summary

• Immunogen: Full length mouse phosphotyrosyl phosphatase activator protein (PTPA).
• Specificity: PTPA.
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTPRA
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Theoretical MW: 38 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Tissue culture supernatant
• Preservative: No Preservative
• Purity: Tissue culture supernatant

Notes

Relevant Entrez Gene Numbers: NM_178001

Alternate Names for PTP alpha/PTPRA Antibody (5G3)

• EC 3.1.3.48
• HEPTP
• HLPR
• LRP
• LRPHPTPalpha
• protein tyrosine phosphatase, receptor type, A
• Protein-tyrosine phosphatase alpha
• PTP alpha
• PTPAreceptor type, alpha polypeptide
• PTPase-alpha
• PTPLCA-related phosphatase
• PTPRA
• PTPRL2
• receptor-type tyrosine-protein phosphatase alpha
• RPTPA
• R-PTP-alpha
• tyrosine phosphatase alpha

Background

PTP alpha is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRA
• Uniprot:
  • Q15257()