PTF1A Antibody

• Reactivity: Ze
• Applications: ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

PTF1A Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence C-EDPRKLHLKSSINN corresponding to internal region according to Uniprot Zebrafish NP_997524.1.
• Epitope: C-EDPRKLHLKSSINN
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PTF1A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PTF1A Antibody

• bHLH transcription factor p48
• BHLHA29
• bHLHa29exocrine pancreas-specific transcription factor p48
• Class A basic helix-loop-helix protein 29
• p48 DNA-binding subunit of transcription factor PTF1
• pancreas specific transcription factor, 1a
• pancreas transcription factor 1 subunit alpha
• Pancreas-specific transcription factor 1a
• PTF1A
• PTF1P48
• PTF1-p48
• PTF1-p48class II bHLH protein PTF1A

Background

PTF1A encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PTF1A Antibody (NB100-93539)(1)

Publication using NB100-93539

• Zecchin E, Mavropoulos A, Devos N et al. Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Dev Biol 2004-04-01 [PMID: 15031114]

Bioinformatics

• Gene Symbol: PTF1A
• Entrez:
  • 256297(Human)
• Uniprot:
  • NP_997524.1(Zebrafish)