PSENEN/PEN2 Antibody

Product Discontinued

PSENEN/PEN2 Antibody Summary

• Immunogen: Antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PEN2. The immunogen is located within the first 50 amino acids of PEN2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PSENEN
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PSENEN/PEN2 Antibody

• gamma-secretase subunit PEN-2
• MSTP064
• PEN-2
• PEN2hematopoietic stem/progenitor cells protein MDS033
• presenilin enhancer 2 homolog (C. elegans)
• Presenilin enhancer protein 2
• PSENEN

Background

PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic A'beta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSENEN
• Uniprot:
  • NP_758844(Human)