Western Blot: Prohibitin 2 Antibody [NB100-1809] - Detection of Human and Mouse REA on HeLa whole cell lysate using NB100-1809. REA was also immunoprecipitated using rabbit anti-REA antibodies NB100-1807 and NB100-1808.
The immunogen recognized by this antibody maps to a region between residue 250 and the C-terminus (residue 299) of human Repressor of Estrogen Activity (Prohibitin 2) using the numbering given in entry NP_009204.1 (GeneID 11331).
Immunogen affinity purified
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REA (repressor of estrogen receptor activity), also known as prohibitin 2, has been shown to exhibit a variety of functions that includes mitochondrial chaperone activity, cell cycle regulation, and transcriptional regulation. REA localizes to the mitochondria and associates with mitochondrial complex I where it may play a role in mitochondrial metabolism. REA interacts with pRb to inhibit E2F-mediated transcription as well as the estrogen receptor to repress estrogen-dependent transcription via recruitment of histone deacetylases. Alternate names for REA include B-cell receptor-associated protein BAP37, D-prohibitin, PHB2, BAP, p22, BCAP37, PNAS-141, and MGC117268.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.