Potassium Channel Kv3.1 Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cell line U-2 OS shows localization to nucleus, nuclear membrane and cytosol. Antibody staining shown in green.

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human kidney shows no positivity in cells in tubules as expected.

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Analysis in human cerebral cortex and kidney tissues. Corresponding KCNC1 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human small intestine shows no positivity in glandular cells as expected.

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cerebellum shows moderate to strong cytoplasmic positivity in granular layer.

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cerebral cortex shows weak to moderate cytoplasmic positivity in neurons.

• Reactivity: Hu, Mu, Rt
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Potassium Channel Kv3.1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Potassium Channel Kv3.1 Antibody - BSA Free (NBP2-30395) is a polyclonal antibody validated for use in IHC and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: EEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDS
• Predicted Species: Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNC1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  Potassium Channel Kv3.1 Protein (NBP2-30395PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Potassium Channel Kv3.1 Antibody - BSA Free

• FLJ41162
• FLJ42249
• FLJ43491
• KCNC1
• KV3.1
• KV4
• MGC129855
• NGK2
• Potassium Channel Kv3.1
• potassium voltage-gated channel subfamily C member 1
• potassium voltage-gated channel, Shaw-related subfamily, member 1
• voltage-gated potassium channel protein KV3.1
• Voltage-gated potassium channel subunit Kv3.1
• Voltage-gated potassium channel subunit Kv4

Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNC1
• Uniprot:
  • P48547(Human)