Potassium Channel Kv2.2 Antibody

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Western Blot: Potassium Channel Kv2.2 Antibody [NB300-261] - Rat Brain - The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide block).

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, IHC, IHC-Fr
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Potassium Channel Kv2.2 Antibody Summary

Immunogen
Peptide from the subunit region of the voltage gated potassium channel, Kv2.2 of rat and Xenopus, conjugated to keyhole limpet hemocyanin (KLH).
Localization
Cell Membrane
Specificity
Specific for the ~125k voltage gated potassium channel, Kv 2.2 subunit.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNB2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:1000
  • Immunohistochemistry-Frozen 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for Potassium Channel Kv2.2 Antibody

  • delayed rectifier potassium channel protein
  • KCNB2
  • KV2.2
  • Potassium Channel Kv2.2
  • potassium voltage-gated channel subfamily B member 2
  • potassium voltage-gated channel, Shab-related subfamily, member 2
  • voltage-gated potassium channel subunit Kv2.2

Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KCNB2
Entrez
Uniprot