Polycystin-1/PKD1 Antibody

Immunohistochemistry-Paraffin: Polycystin-1/PKD1 Antibody [NBP1-52552] - Analysis of anti-PKD1 antibody with human kidney at concentration 3.75 ug/ml.

Immunohistochemistry-Paraffin: Polycystin-1/PKD1 Antibody [NBP1-52552] - Analysis of anti-PKD1 antibody with human spleen at concentration 3.75 ug/ml.

• Reactivity: Hu, Pm
• Applications: ELISA, IHC, IP, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Polycystin-1/PKD1 Antibody Summary

• Immunogen: Synthetic peptide C-RTPLRAKNKVHP from the C-terminus of human Polycystin-1/PKD1 (NP_001009944.1; NP_000287.2).
• Epitope: C-RTPLRAKNKVHP from the C-Terminus
• Specificity: Human PKD1. This antibody is expected to recognize both reported isoforms (NP_001009944.1 and NP_000287.2).
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PKD1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 3.75 ug/ml
  • Immunoprecipitation
  • Peptide ELISA
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (83%), Feline (83%), Canine (83%), Equine (83%).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: TBS (pH 7.3) and 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Polycystin-1/PKD1 Antibody

• Autosomal dominant polycystic kidney disease 1 protein
• PBP
• Pc-1
• PKD1
• polycystic kidney disease 1 (autosomal dominant)
• polycystic kidney disease-associated protein
• polycystin 1
• Polycystin1
• Polycystin-1
• transient receptor potential cation channel, subfamily P, member 1
• TRPP1

Background

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (alpha, betaI, betaII and gamma) and novel (n) PKC isoforms (delta, episilon , zeta, eta and theta). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and episilon are independent of Ca++. On the other hand, nPKC delta and episilon, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PKD1
• Entrez:
  • 5310(Human)
• Uniprot:
  • P98161(Human)