PMS2 Antibody (PMS2/8374R) [DyLight 650]

• Reactivity: Hu
• Applications: IHC
• Clone: PMS2/8374R
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: DyLight 650

PMS2 Antibody (PMS2/8374R) [DyLight 650] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant fragment (around aa1-200) of human PMS2 protein (exact sequence is proprietary)
• Localization: Nucleus.
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PMS2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PMS2 Antibody (PMS2/8374R) [DyLight 650]

• DNA mismatch repair protein PMS2
• EC 3.1
• H_DJ0042M02.9
• HNPCC4postmeiotic segregation increased (S. cerevisiae) 2
• mismatch repair endonuclease PMS2
• PMS1 protein homolog 2
• PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
• PMSL2PMS2CL

Background

PMS2 is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PMS2