PMEL17/SILV Antibody (P14-V)

Immunohistochemistry-Paraffin: PMEL17/SILV Antibody (P14-V) [NBP1-79001] - Diffuse anti Melanosome antibody positivity in the cutaneous malignant melanoma. Formalin fixed, paraffin embedded human tissue (4 um section) stained with anti -Melanosome (DB 049) monospecific clonal antibody.

Product Discontinued

PMEL17/SILV Antibody (P14-V) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Peptide derived from C-terminal sequence of human PMEL17/SILV/gp100. Antibody recognizes the epitope between Ile649 - Val661.
• Epitope: Ile649 - Val661
• Marker: Melanosome Marker
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PMEL
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:200
  • Immunohistochemistry-Paraffin 1:100-1:200
• Application Notes: Although not tested, this antibody may also be useful in Immunohistochemistry-Frozen.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 20mM Tris-HCl (pH 8.0) and 20mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

Alternate Names for PMEL17/SILV Antibody (P14-V)

• D12S53EP1
• Gp100
• ME20
• ME20M
• ME20-M
• melanocyte protein mel 17
• Melanocyte protein Pmel 17
• Melanocytes lineage-specific antigen GP100
• Melanoma-associated ME20 antigen
• melanosomal matrix protein17
• PMEL
• PMEL17
• PMEL17P100
• premelanosome proteinME20M
• SI
• SIL
• SILV
• silver (mouse homolog) like
• silver homolog (mouse)
• Silver locus protein homolog
• silver, mouse, homolog of
• SILVPmel17

Background

Melanoma gp100 a melanosomal matrix protein whose expression is closely correlated with cellular melanin content and which is a frequent melanoma tumor antigen recognized by cytotoxic T lymphocytes. It is a likely candidate gene for some cases of human oculocutaneous albinism not associated with known albinism loci.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PMEL