PLC-gamma 2 [p Tyr759] Antibody (MM0872-27K18) [DyLight 650]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-36792C
    • Availability
      Product Discontinued

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PLC-gamma 2 [p Tyr759] Antibody (MM0872-27K18) [DyLight 650] Summary

Immunogen
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells) from a mouse immunized with Phosphopeptide containing Y759 of human PLC gamma -2
Modification
p Tyr759
Specificity
This antibody recognizes human PLC gamma-2 of pY759 in direct ELISAs and WBs.
Isotype
IgG2
Clonality
Monoclonal
Host
Mouse
Gene
PLCG2
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PLC-gamma 2 [p Tyr759] Antibody (MM0872-27K18) [DyLight 650]

  • EC 3.1.4.11
  • Phosphoinositide phospholipase C-gamma-2
  • phospholipase C gamma 2
  • phospholipase C, gamma 2 (phosphatidylinositol-specific)
  • phospholipase C, gamma 2 (phosphatidylyinositol-specific)
  • Phospholipase C-gamma-2,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
  • Phospholipase C-IV
  • PLCG2
  • PLCgamma 2
  • PLC-gamma 2
  • PLC-gamma-2
  • PLC-IV

Background

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. The phospholipase C gamma-2 (PLCgammaII) is an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate (1). PLCgammaII has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLCgammaII (2). It has also been shown that PLCgammaII was required for receptor activator of NF-kappaB ligand-induced (RANKL-induced) osteoclastogenesis by differentially regulating nuclear factor of activated T cells c1 (NFATc1), activator protein-1 (AP1), and NF-kappaB (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Bioinformatics

Gene Symbol PLCG2