PLC-gamma 2 Products

Description

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. The phospholipase C gamma-2 (PLCgammaII) is an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate (1). PLCgammaII has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLCgammaII (2). It has also been shown that PLCgammaII was required for receptor activator of NF-kappaB ligand-induced (RANKL-induced) osteoclastogenesis by differentially regulating nuclear factor of activated T cells c1 (NFATc1), activator protein-1 (AP1), and NF-kappaB (3).

Bioinformatics

Entrez	234779 Mouse 29337 Rat 5336 Human
Uniprot	AAH07565 Human AAH07565.1 Human NM_002661 Human P16885 Human
Product By Gene ID	5336
Alternate Names	EC 3.1.4.11 Phosphoinositide phospholipase C-gamma-2 phospholipase C gamma 2 phospholipase C, gamma 2 (phosphatidylinositol-specific) phospholipase C, gamma 2 (phosphatidylyinositol-specific) Phospholipase C-gamma-2,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 Phospholipase C-IV PLCG2 PLC-gamma-2 PLC-IV

Research Areas for PLC-gamma 2

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Phospho-Specific