PEX12 Antibody

Product Discontinued

PEX12 Antibody Summary

• Immunogen: Peptide with sequence RSHQACPITGYP corresponding to C-Terminus according to NP_000277.1.
• Epitope: RSHQACPITGYP - C Terminus
• Predicted Species: Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PEX12
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: Preliminary experiments in human, mouse and rat liver lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for PEX12 Antibody

• PAF3
• PAF-3
• peroxin 12
• peroxin-12
• peroxisomal biogenesis factor 12
• Peroxisome assembly factor 3
• peroxisome assembly protein 12

Background

The peroxisome biogenesis disorders (PBDs; MIM 601539) are a group of genetically heterogeneous diseases that are usually lethal in early infancy. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. This cellular phenotype is shared by yeast 'pex' mutants, and human orthologs of yeast PEX genes defective in some PBD complementation groups (CGs).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PEX12 Antibody (NBP1-49893)(1)

Publication using NBP1-49893

• Yik WY, Steinberg SJ, Moser AB et al. Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. Hum Mutat 2009-03-01 [PMID: 19105186]

Bioinformatics

• Gene Symbol: PEX12
• Entrez:
  • 5193(Human)
  • 103737(Mouse)
  • 116718(Rat)
• Uniprot:
  • NP_000277.1(Human)