PER1 Antibody

Immunohistochemistry-Paraffin: PER1 Antibody [NBP2-24692] - Analysis of PER1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and NBP2-24692 (bottom left, right) at 5 ug/ml.

Product Discontinued

PER1 Antibody Summary

• Immunogen: A portion of amino acids 30-80 of mouse PER1 was used as the immunogen.
• Predicted Species: Virus (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PER1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in strains H1N1, H3N2, H5N1, H6N1, H6N2 and H9N2, and 93% homologous in H7N7.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for PER1 Antibody

• Circadian clock protein PERIOD 1
• Circadian pacemaker protein Rigui
• hPER1
• KIAA0482
• PER1
• PERhPER
• period (Drosophila) homolog 1
• period circadian protein homolog 1
• period homolog 1 (Drosophila)
• Period, drosophila, homolog of
• PERIOD1
• RIGUI
• RIGUIMGC88021

Background

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PER1