Peptide YY Antibody

ELISA: Peptide YY Antibody [NB100-75583] - Peptide as test antigen. Affi-pure IgY as primary antibody and Goat anti-IgY-HRP as 2nd antibody. Fixed amount of IgY (0.1 ug/ml) and serial dilutions of Ag. ( anti-Pyy )

Product Discontinued

Peptide YY Antibody Summary

• Immunogen: The immunogen for this antibody was a sequence from 29a.a. to 40a.a. from Peptide YY(a 98a.a. long protein)
• Localization: Secreted protein.
• Specificity: Peptide YY
• Clonality: Polyclonal
• Host: Chicken
• Gene: PYY
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: ELISA: Peptide as test antigen. Affi-pure IgY as primary antibody and Goat anti-IgY-HRP as 2nd antibody. Fixed amount of IgY (0.1 ug/ml) and serial dilutions of Ag.

Reactivity Notes

This antibody is reactive against Human, mouse, rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Chicken products cannot be exported to Canada.

Alternate Names for Peptide YY Antibody

• Peptide tyrosine tyrosine
• Peptide YY
• Peptide-YY
• PYY
• PYY1
• PYY-I

Background

Peptide tyrosine tyrosine (PYY) was originally isolated from porcine gut, which exhibits striking sequence homology with members of the pancreatic polypeptide family, including neuropeptide tyrosine (NPY). The peptide is localized to enteroglucagon containing (L/EG) and pancreatic (A) cells in many mammalian and non-mammalian species. PYY gene expression is upregulated by various growth factors, including growth hormone and insulin-like growth factor and the physiological effects of PYY are mediated by G-protein (G alpha i2) coupled Y-type receptors ('Y2 receptors of a PYY preferring subtype'). Various actions have been reported for PYY, including the inhibition of upper intestinal and exocrine pancreatic secretion, small intestinal water flux and as the mediator for the fat-induced ileal brake. Recently, the infusion of normal postprandial concentrations of PYY[3-36] into human volunteers has been shown to significantly decrease appetite and reduce food intake, possibly via Y2R in the arcuate nucleus. Immunohistochemical studies on mice have shown that PYY is the earliest detectable peptide in both pancreatic islets and colonic endocrine cells which suggest that PYY may be a useful marker for endocrine progenitor cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PYY
• Entrez:
  • 287730(E. faecalis)
  • 5697(Human)
  • 217212(Mouse)
• Uniprot:
  • Q9EPS2(Mouse)