PCPE-1/PCOLCE Antibody [Alexa Fluor® 350]

• Applications: WB, IP
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

PCPE-1/PCOLCE Antibody [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PCPE-1
  Met1-Asp449
  Accession # Q15113
• Specificity: Detects human PCPE-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 45% cross-reactivity with recombinant mouse PCPE-1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

PCPE-1 is a 55 kDa extracellular protein that lacks intrinsic enzymatic activity. It functions as a substrate-specific adaptor protein that stimulates C-terminal processing of the fibrillar procollagens I, II and III by PCP (also known as BMP-1/tolloid metalloproteinases). PCPE is naturally processed into N-terminal fragments of 34 and 36 kDas, both of which also enhance PCP. A 16.5 kDa protein corresponding to a C-terminal fragment of PCPE has been described and shown to have metalloproteinase inhibitor activity. Human PCPE-1 shares approximately 81% amino acid sequence homology with mouse and rat PCPE-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.