Pannexin-2 Antibody (719406) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clone: 719406
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Pannexin-2 Antibody (719406) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human Pannexin-2
  Arg316-Lys456
  Accession # Q96RD6
• Specificity: Detects human Pannexin-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human (rh) Pannexin-1 and no cross-reactivity with rhPannexin-3 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Pannexin-2 Antibody (719406) [Alexa Fluor® 700]

• hPANX2
• MGC119432
• pannexin 2
• Pannexin2
• Pannexin-2
• PANX2
• PX2

Background

Pannexin 2 (PANX2) is a ~60 kDa, 677 amino acid (aa) protein of the pannexin family of four-transmembrane channel proteins with a conserved pattern of cysteines. PANX2 can interact with PANX1. It is mainly expressed on postnatal neural progenitors and is thought to inhibit the rate of neuronal differentiation. PANX2 expression is positively correlated with survival following glioma diagnosis, and it negatively regulates glioma cell line growth. Polymorphisms of PANX2 are associated with bipolar disorder and schizophrenia. Within aa 316‑456, human PANX2 shares 96% aa sequence identity with mouse and rat PANX2. A 643 aa isoform diverges after aa 631, while a 509 aa isoform also shows an alternate start site at aa 135.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.