p27/Kip1 Antibody (SX53G8) [DyLight 680]

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Product Details

Summary
Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP
Clone
SX53G8
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Order Details

p27/Kip1 Antibody (SX53G8) [DyLight 680] Summary

Immunogen
Purified GST-p27 fusion protein of human origin
Localization
Nuclear
Specificity
This MAb recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1, ZR75-30, MCF-7, MDAMB453, T47D, CAL51, 734B), the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDKN1B
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA 1-5ug/ml for coating
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for p27/Kip1 Antibody (SX53G8) [DyLight 680]

  • CDKN1B
  • CDKN4
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cyclin-dependent kinase inhibitor 1B
  • Cyclin-dependent kinase inhibitor p27
  • Kip1
  • KIP1P27KIP1
  • MEN1B
  • MEN4
  • p27
  • p27Kip1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for p27/Kip1 Antibody (NBP2-34718FR) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-34718AF350
Alexa Fluor 405 NBP2-34718AF405
Alexa Fluor 488 NBP2-34718AF488
Alexa Fluor 532 NBP2-34718AF532
Alexa Fluor 594 NBP2-34718AF594
Alexa Fluor 647 NBP2-34718AF647
Alexa Fluor 700 NBP2-34718AF700
Alexa Fluor 750 NBP2-34718AF750
Allophycocyanin NBP2-34718APC
Allophycocyanin/Cy7 NBP2-34718APCCY7
Biotin NBP2-34718B
DyLight 350 NBP2-34718UV
DyLight 405 NBP2-34718V
DyLight 488 NBP2-34718G
DyLight 550 NBP2-34718R
DyLight 594 NBP2-34718DL594
DyLight 650 NBP2-34718C
DyLight 680 NBP2-34718FR
DyLight 755 NBP2-34718IR
HRP NBP2-34718H
Janelia Fluor 549 NBP2-34718JF549
Janelia Fluor 646 NBP2-34718JF646
PE NBP2-34718PE
PE/Atto594 NBP2-34718PEATT594
PE/Cy5.5 NBP2-34718PECY55
PE/Cy7 NBP2-34718PECY7
PerCP NBP2-34718PCP

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Bioinformatics

Gene Symbol CDKN1B