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p27/Kip1 Products

Antibodies
p27/Kip1 [p Thr157] Antibody
p27/Kip1 [p Thr157] Antibody
AF1555
291-G1) for 20 minutes. PVDF membrane was probed with 0.5 µg/mL Human Phospho-p27/Kip1 (T157) Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1555) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band for Phospho-p27/Kip1 (T157) was detected at approximately 27 kDa (as indicated). The phospho-specificity of this antibody was supported by decreased labeling following treatment with 600 U lambda-phosphatase (lambda-PPase) for 1 hour. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank"> Western Blot p27/Kip1 [p Thr157] Antibody
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
p27/Kip1 [p Thr198] Antibody ...
p27/Kip1 [p Thr198] Antibody [Unco...
AF3994
HAF008). A specific band for p27/Kip1 was detected at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank"> Western Blot p27/Kip1 [p Thr198] Antibody [Unconjugated]
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
ELISA Kits
Human p27/Kip1 ELISA Kit (Col ...
Human p27/Kip1 ELISA Kit (Colorime...
NBP2-66683
Species: Hu
Applications: ELISA
Mouse p27/Kip1 ELISA Kit (Col ...
Mouse p27/Kip1 ELISA Kit (Colorime...
NBP2-75208
Species: Mu
Applications: ELISA
Human Total p27/Kip1 DuoSet I ...
Human Total p27/Kip1 DuoSet IC ELI...
DYC2256-2
Applications: ELISA
Conjugate Catalog # Availability Size Price
Lysates
p27/Kip1 293T Cell Transient ...
p27/Kip1 293T Cell Transient Overe...
H00001027-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human p27/Kip1 Hi ...
Recombinant Human p27/Kip1 His Pro...
NBP1-72503
Species: Hu
Applications: PAGE
p27/Kip1 Recombinant Protein ...
p27/Kip1 Recombinant Protein Antigen
NBP2-56105PEP
Species: Hu
Applications: AC

Description

p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27(Kip1) binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27(Kip1) is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27(Kip1) (2); while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm (3).

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Chicken
Product By Gene ID 1027
Alternate Names
  • CDKN4
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cyclin-dependent kinase inhibitor 1B
  • Cyclin-dependent kinase inhibitor p27
  • KIP1P27KIP1
  • MEN1B
  • MEN4
  • p27Kip1

Research Areas for p27/Kip1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
DNA Repair
Phospho-Specific
Prostate Cancer
Tumor Suppressors