p21/CIP1/CDKN1A Antibody (CIP1/823) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, Mu(-), Rt(-)Species Glossary
Applications Flow, IHC, IHC-P, ICC/IF
Clone
CIP1/823
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

p21/CIP1/CDKN1A Antibody (CIP1/823) [Janelia Fluor® 549] Summary

Immunogen
Recombinant full-length human CDKN1A protein
Localization
Nuclear
Specificity
This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDKN1A
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Alternate Names for p21/CIP1/CDKN1A Antibody (CIP1/823) [Janelia Fluor® 549]

  • CAP20cyclin-dependent kinase inhibitor 1
  • CDK-interacting protein 1
  • CDKN1A
  • CDKN1melanoma differentiation associated protein 6
  • CIP1
  • CIP1WAF1CDK-interaction protein 1
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)
  • MDA6
  • MDA-6
  • Melanoma differentiation-associated protein 6
  • p21
  • p21CIP1
  • p21Cip1/Waf1
  • PIC1
  • SDI1DNA synthesis inhibitor
  • wild-type p53-activated fragment 1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47783AF350
Alexa Fluor 405 NBP2-47783AF405
Alexa Fluor 488 NBP2-47783AF488
Alexa Fluor 532 NBP2-47783AF532
Alexa Fluor 594 NBP2-47783AF594
Alexa Fluor 647 NBP2-47783AF647
Alexa Fluor 700 NBP2-47783AF700
Alexa Fluor 750 NBP2-47783AF750
Allophycocyanin NBP2-47783APC
Allophycocyanin/Cy7 NBP2-47783APCCY7
Biotin NBP2-47783B
DyLight 350 NBP2-47783UV
DyLight 405 NBP2-47783V
DyLight 488 NBP2-47783G
DyLight 550 NBP2-47783R
DyLight 594 NBP2-47783DL594
DyLight 650 NBP2-47783C
DyLight 680 NBP2-47783FR
DyLight 755 NBP2-47783IR
FITC NBP2-47783F
HRP NBP2-47783H
Janelia Fluor 549 NBP2-47783JF549
Janelia Fluor 646 NBP2-47783JF646
PE NBP2-47783PE
PE/Atto594 NBP2-47783PEATT594
PE/Cy5.5 NBP2-47783PECY55
PE/Cy7 NBP2-47783PECY7
PerCP NBP2-47783PCP

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Bioinformatics Tool for p21/CIP1/CDKN1A Antibody (NBP2-47783JF549)

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Bioinformatics

Gene Symbol CDKN1A