p130 Antibody (KAB40)

Product Discontinued

p130 Antibody (KAB40) Summary

• Immunogen: Recombinant protein to the N terminus of p130
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: RBL2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.08% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for p130 Antibody (KAB40)

• FLJ26459
• P130
• PRB2
• Rb2
• RBR-2
• retinoblastoma-like 2 (p130)
• retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein
• Retinoblastoma-related protein 2

Background

The immunogen used was a recombinant protein to the N terminus of p130. p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107(collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors. This antibody recognizes both the phosphorylated and unphosphorylated forms of p130 at a MW of 130kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RBL2