Recombinant Human Otubain-1 Protein

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SDS-Page: OTUB1 Protein [NBP1-30186] - Otubain 1, 33.4 kDa (291aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human Otubain-1 Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-271 of Human Otubain-1

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
OTUB1
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Theoretical MW
33.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20 mM Tris buffer (pH 8.0) containing 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human Otubain-1 Protein

  • Deubiquitinating enzyme OTUB1
  • EC 3.1.2
  • EC 3.4.19.12
  • FLJ20113
  • FLJ40710
  • hOTU1
  • MGC111158
  • OTB1
  • OTB1MGC4584
  • OTU domain, ubiquitin aldehyde binding 1
  • OTU domain-containing ubiquitin aldehyde-binding protein 1
  • OTU1
  • OTU1OTU-domain Ubal-binding 1
  • OTUB1
  • Otubain1
  • Otubain-1
  • ubiquitin thioesterase OTUB1
  • ubiquitin-specific protease otubain 1
  • Ubiquitin-specific-processing protease OTUB1

Background

Otubain 1, also known as OTUB1, is a member of the OUT (ovarian tumor) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system via its interaction with a ubiquitin protease and E3 ubiquitin ligase. This protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. Recombinant OTUB1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol OTUB1
Entrez