Olfactomedin-2/Noelin-2 Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Biotin
Concentration
LYOPH

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Olfactomedin-2/Noelin-2 Antibody [Biotin] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Olfactomedin‑2/Noelin‑2
Gln21-Pro454
Accession # O95897
Specificity
Detects human Olfactomedin‑2/Noelin‑2 in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant mouse (rm) Olfactomedin‑1 is observed and less than 5% cross-reactivity recombinant human Olfactomedin-4 and rmOlfactomedin-L3 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
OLFM2
Purity
Antigen Affinity-purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Purity
Antigen Affinity-purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Olfactomedin-2/Noelin-2 Antibody [Biotin]

  • neuronal olfactomedin related ER localized protein 2
  • NOE2
  • NOE2noelin 2
  • NOELIN2
  • Noelin-2
  • NOELIN2_V1
  • olfactomedin 2
  • Olfactomedin2
  • Olfactomedin-2
  • OlfC
  • OLFM2
  • OM2

Background

Olfactomedin-2 (OLFM2, OM2), also called OlfC or neuronal olfactomedin-related endoplasmic reticulum-localized-2 (Noelin-2) is a 50 kDa (predicted), secreted member of the olfactomedin/noelin family of proteins (1‑3). Since Noelin-2 has also been used to designate an alternately spliced form of Noelin-1, Olfactomedin-2 is the less ambiguous name (4). Olfactomedin domain-containing proteins are often found in neural tissues (3). Human Olfactomedin-2 expressed sequence tags have mainly been found in the brain and eye, and RNA in the cerebellum (1, 2). In zebrafish, Olfactomedin-2 expression is developmentally regulated and, like Noelin-1, may play a role in neural crest cell differentiation (5). The human Olfactomedin-2 cDNA encodes a 20 amino acid (aa) signal sequence and a 454 mature protein that contains two coiled-coil regions (aa 58‑85 and 136‑193) and an Olfactomedin domain (aa 194‑446). Mature human Olfactomedin-2 shares 98% aa identity with rat, bovine and equine, 97% with mouse and canine, 81% with Xenopus, and 77% with zebrafish Olfactomedin-2. No alternate splice variants have been reported for Olfactomedin-2 (1). Polymorphisms of human Olfactomedin-2, with or without additional polymorphisms in optineurin (OPTN), have been associated with a small fraction of high intraocular pressure or open-angle glaucoma cases in Japanese patients (6). The family member myocilin shows stronger association with these ocular disorders, and either myocilin or Noelin-1 might heterodimerize with Olfactomedin-2 (1). Evidence suggests that Olfactomedin-2 has evolved from Noelin-1 gene duplication, and myocilin from Olfactomedin-2 gene duplication (1).

  1. Mukhopadhyay, A. et al. (2004) Mol. Vis. 10:304.
  2. Kulkarni, N.H. et al. (2000) Genet. Res. Camb. 76:41.
  3. Tomarev, S.I. and N. Nakaya (2009) Mol. Neurobiol. 40:122.
  4. Moreno, T.A. & M. Bronner-Fraser (2002) Mech. Dev. 119:121.
  5. Lee, J-A. et al. (2008) Mech. Dev. 125:167.
  6. Funayama, T. et al. (2006) Invest. Ophthalmol. Vis. Sci. 47:5368.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Biotin BAF5614

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Bioinformatics

Gene Symbol OLFM2
Uniprot