NONO Antibody (78-1 C)

Immunohistochemistry-Paraffin: NONO Antibody (78-1 C) [NB100-74478] - Both normal and cancer biopsies of deparaffinized human Kidney tissue.

Immunohistochemistry-Paraffin: NONO Antibody (78-1 C) [NB100-74478] - Both normal and cancer biopsies of deparaffinized human Tonsil tissue.

Immunohistochemistry-Paraffin: NONO Antibody (78-1 C) [NB100-74478] - Both normal and cancer biopsies of deparaffinized human Bladder carcinoma tissue.

Product Discontinued

NONO Antibody (78-1 C) Summary

• Immunogen: Synthetic peptide corresponding to residues T(140) V R E A G P P A F Y R P N S(154) of human ER alpha.
• Localization: Nuclear
• Specificity: nmt55 / p54nrb (78-1 C)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: NONO
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot 1:1000
• Control:

  NONO Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.05% Sodium Azide
• Purity: Unpurified

Alternate Names for NONO Antibody (78-1 C)

• NMT5552 kDa subunit
• non-POU domain containing, octamer-binding
• NRB54non-POU-domain-containing, octamer-binding
• p54(nrb)

Background

Nmt55/p54nrb is an RNA binding protein that has been implicated in multiple cellular functions such as regulation of cell division as well as cancer biology. Expression of this protein has been found to be decreased in some human breast tumors, and has been studied as a relevant tumor marker. It has been found, that decreased nmt55/p54nrb expression in Estrogen Receptor (ER) negative human breast tumors or the expression of nmt55/p54nrb variants in ER positive tumors may indicate the loss of normal growth. It is possible that nmt55/p54nrb acts as a pre-mRNA splicing factor affecting the structure and function of hERalpha.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NONO
• Entrez:
  • 4841(Human)
  • 317259(Rat)