Nociceptin Antibody

Images

 
Orthogonal Strategies: Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining in human cerebral cortex and colon tissues using anti-PNOC antibody. Corresponding PNOC RNA-seq data are presented ...read more
Independent Antibodies: Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human cerebral cortex, colon, liver and testis using Anti-PNOC anibody NBP2-58314 (A0 shows similar protein ...read more
Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human cerebral cortex shows high expression.
Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human colon shows low expression as expected.
Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human testis.
Immunohistochemistry-Paraffin: Nociceptin Antibody [NBP2-58314] - Staining of human liver.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Nociceptin Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: RVRSLFQEQEEPEPGMEEAGEMEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQ
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PNOC
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Nociceptin Recombinant Protein Antigen (NBP2-58314PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Nociceptin Antibody

  • nociceptin
  • nocistatin
  • OFQ
  • P
  • PPNOC
  • prepronociceptin
  • propronociceptin

Background

Nociceptin (Orphanin FQ, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand for the ORL1 receptor. The amino acid sequence of nociceptin hashomology with other opioid peptides, especially the prodynorphin fragment dynorphin A, suggesting a close evolutionary relationship between the precursors. A diffuse distribution throughout the brain is seen with binding studies and in situ hybridization suggesting an extensive role for nociceptin in a multitude of CNS functions. Immunocytochemical localizations in rat spinal cord have demonstrated nociceptin abundance in superficial dorsal horn, lateral spinal nucleus and the region dorsal to the central canal. Nociceptin immunoreactivity was not affected by dorsal rhizotomy, indicating that in spinal cord the peptide is produced by central rather than primary afferent neurons. The localization is supported by its function in processing of nociceptive signals.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PNOC