NMRAL1 Recombinant Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.5 mg/ml

Order Details

NMRAL1 Recombinant Protein Summary

Description
A recombinant protein with a His-tag corresponding to amino acids 1 to 299 of Human NMRAL1

Source: E. coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMVDKKL VVVFGGTGAQ GGSVARTLLE DGTFKVRVVT RNPRKKAAKE LRLQGAEVVQ GDQDDQVIME LALNGAYATF IVTNYWESCS QEQEVKQGKL LADLARRLGL HYVVYSGLEN IKKLTAGRLA AAHFDGKGEV EEYFRDIGVP MTSVRLPCYF ENLLSHFLPQ KAPDGKSYLL SLPTGDVPMD GMSVSDLGPV VLSLLKMPEK YVGQNIGLST CRHTAEEYAA LLTKHTRKVV HDAKMTPEDY EKLGFPGARD LANMFRFYAL RPDRDIELTL RLNPKALTLD QWLEQHKGDF NLL
Gene
NMRAL1
Purity
>95% pure by SDS-PAGE

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.15M NaCl
Concentration
0.5 mg/ml
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Application Notes
This product is useful for SDS-PAGE. The purity of this protein is > 95% by SDS - PAGE.

Reactivity Notes

Human

Alternate Names for NMRAL1 Recombinant Protein

  • HSCARGFLJ25918
  • NmrA-like family domain containing 1
  • nmrA-like family domain-containing protein 1
  • SDR48A1
  • short chain dehydrogenase/reductase family 48A, member 1

Background

NMRAL1 is a redox sensor protein that undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. Recombinant human NMRAL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol NMRAL1

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